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    <ns0:brs_depositor xml:lang="ja">中山　俊憲</ns0:brs_depositor>
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    <ns1:strainDevelopment xml:lang="ja">開発年：2002年開発者：新海浤先生機関名：千葉大学　大学院医学研究院</ns1:strainDevelopment>
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    <ns1:donorDNA>herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse Dpt genomic DNA</ns1:donorDNA>
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    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="https://www.m.chiba-u.ac.jp/class/meneki/english/" target="_blank"&gt;Lab HP&lt;/A&gt;</ns5:addinfo>
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    <ns1:colonyMaintenance xml:lang="ja">繁殖効率：B 野生型と同様、ホモで維持できる。</ns1:colonyMaintenance>
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    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns1:colonyMaintenance xml:lang="ja">繁殖効率：B野生型と同様、ホモで維持できる。</ns1:colonyMaintenance>
    <ns1:strainDevelopment xml:lang="ja">開発年：2002年 開発者：新海浤先生 機関名：千葉大学　大学院医学研究院</ns1:strainDevelopment>
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    <ns0:brs_depositor xml:lang="en">Toshinori NAKAYAMA</ns0:brs_depositor>
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    <ns7:SIO_001279 rdf:parseType="Resource">
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    <ns0:brs_depositorOrganization xml:lang="ja">国立大学法人千葉大学</ns0:brs_depositorOrganization>
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    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <rdfs:label>B6.129-Dpt&lt;tm1Hsh&gt;/NakaRbrc</rdfs:label>
    <ns5:application>Cell Biology Research</ns5:application>
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    <ns1:strainDevelopment xml:lang="en">Developed by Dr. Hroshi Shinkai, Chiba University at 2002.  A pgk-neo was transfered into ES cells to relpace exon 1 of Dpt gene.</ns1:strainDevelopment>
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    <ns5:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Invest. Dermatol., 119, 678-683 (2002).</ns5:termsAndConditions>
    <skos:altLabel xml:lang="ja">Dermatopontin KO mice</skos:altLabel>
    <skos:altLabel xml:lang="en">Dermatopontin KO mice</skos:altLabel>
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    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)Homozygote mutant mice are fertile.</ns1:colonyMaintenance>
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    <dc:description xml:lang="ja">Dermatopontin 遺伝子の第一エキソンをネオマイシン耐性遺伝子に置き換えた Dermatopontin 遺伝子欠損マウス。</dc:description>
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    <ns0:brs_depositorOrganization xml:lang="en">Chiba Univ.</ns0:brs_depositorOrganization>
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    <rdfs:label xml:lang="en">Dermatopontin KO mice</rdfs:label>
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    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl) Homozygote mutant mice are fertile.</ns1:colonyMaintenance>
    <dc:description xml:lang="en">Dermatopontin (Dpt) is a collagen-associated protein, is widely distributed in extracellular matrix.   Homozygote mutant mice not exhibit any obvious anatomical abnormality, but the skin elasticity was increased.  This strain is useful for study of the mechanism and the process of collagen fibrillogenesis.</dc:description>
    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。J. Invest. Dermatol., 119, 678-683 (2002).</ns5:termsAndConditions>
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    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr01458'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
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